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SUMMARY:Brillouin confocal microscopy for non-invasive 3D imaging of biomec
 hanical properties
LOCATION:Virtual Seminar
TZID:America/Denver
DTSTART:20200101T000000
UID:2026-04-29-00-04-56@natsci.colostate.edu
DTSTAMP:20260429T000456
Description:Literature Seminar\n\nBiomechanical properties of cells have em
 erged as an important indicator in characterizing cancer tumor progression
 . Traditional biomechanical techniques are quite limited. Most are conside
 red invasive and cannot be used to study the depth of both cellular and ti
 ssue microenvironments.  Brillouin confocal microscopy is a non-invasive\
 , 3D optical technique commonly used in materials science and condensed ma
 tter physics to measure elastic properties. Similar to Raman light scatter
 ing\, Brillouin light scattering is the inelastic scattering of light from
  acoustic phonons within a sample. Although previously limited in its appl
 ication to biological samples\, the recent development of the Virtually Im
 aged Phase Array (VIPA) spectrometer has allowed Brillouin confocal micros
 copy to emerge as a powerful tool in biomechanical studies.  In this talk
 \, I will review a study with three key aims: (1) To showcase the potentia
 l for noncontact\, high-resolution 3D-imaging using Brillouin confocal mic
 roscopy\; (2) validation of Brillouin confocal microscopy against atomic f
 orce microscopy (AFM)\; and (3) the ability to demonstrate the effect of a
  common cancer therapeutic on cancer nodules using Brillouin confocal micr
 oscopy.\n\n&nbsp\;\n\n 	Nikolić\, Miloš\, Christina Conrad\, Jitao Zhang
 \, and Giuliano Scarcelli. “Noninvasive Imaging: Brillouin Confocal Micr
 oscopy.” In Biomechanics in Oncology\, edited by Cheng Dong\, Nastaran Z
 ahir\, and Konstantinos Konstantopoulos\, 351–64. Advances in Experiment
 al Medicine and Biology. Cham: Springer International Publishing\, 2018. h
 ttps://doi.org/10.1007/978-3-319-95294-9_16.\n 	Caponi\, Silvia\, Claudio 
 Canale\, Ornella Cavalleri\, and Massimo Vassalli. “Characterization Too
 ls for Mechanical Probing of Biomimetic Materials.” In Nanotechnology Ch
 aracterization Tools for Tissue Engineering and Medical Therapy\, edited b
 y Challa S.S.R. Kumar\, 69–111. Berlin\, Heidelberg: Springer\, 2019. ht
 tps://doi.org/10.1007/978-3-662-59596-1_2.\n 	Palombo\, F.\; Fioretto\, D.
  Brillouin Light Scattering: Applications in Biomedical Sciences.  Rev. 20
 19\, 119 (13)\, 7833-7847. DOI: 10.1021/acs.chemrev.9b00019\n 	Conrad\, C.
 \; Gray\, K. M.\; Stroka\, K. M.\; Rizvi\, I.\; Scarcelli\, G. Mechanical 
 Characterization of 3D Ovarian Cancer Nodules Using Brillouin Confocal Mic
 roscopy. Cell Mol Bioeng 2019\, 12 (3)\, 215-226. DOI: 10.1007/512195-019-
 00570-7\n 4:30 pm
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