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SUMMARY:A Composite Nanomaterial for Protecting DNA Barcodes from Environme
 ntal Degradation
LOCATION:Virtual Seminar
TZID:America/Denver
DTSTART:20210426T160000
UID:2026-04-24-01-18-43@natsci.colostate.edu
DTSTAMP:20260424T011843
Description:Research Seminar\n\nBarcoding technology for object tracking co
 ntinues to evolve in form\, complexity and security. Recently\, DNA has be
 en used as a barcode allowing the user to encode information within the nu
 cleic sequence\, increasing the material’s storage density. However\, th
 e susceptibility of DNA to environmental damage (e.g.\, nuclease and ultra
 violet (uv) light exposure) limits the efficacy of the barcode. Porous pro
 tein crystals ‘capped’ with zinc oxide nanoparticles (ZnONPs) have the
  potential to house and protect DNA barcodes. While ZnONPs have been well 
 studied\, it remains less understood how the inherent properties of ZnONPs
  perform following immobilization around DNA barcode loaded protein crysta
 ls. Specific Aim 1 entails functionalizing ZnONPs with thiol-terminated po
 lyethylene glycol (SH-PEG) allowing for crystal installation via surface-e
 xposed cysteine residues. Specific aim 2 entails detecting for crystal-loa
 ded DNA damage following incubation with nuclease and exposure to uv-light
 \, respectively.\n\nJoin Zoom Meeting\nMeeting ID: 991 5275 1265\nPasscode
 : 1872 4:00 pm
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