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SUMMARY:Structure-based discovery of new functions in large RNAs
LOCATION:Virtual Seminar
TZID:America/Denver
DTSTART:20200201T000000
UID:2026-05-16-02-08-30@natsci.colostate.edu
DTSTAMP:20260516T020830
Description:The functions of many RNA molecules – including mRNAs\, long 
 non-coding RNAs\, and the genomes of RNA viruses – require that an RNA f
 old back on itself to create intricately and complexly folded structures. 
 Until recently\, however\, we had little idea of the broad interrelationsh
 ips between RNA structure and function because there simply did not exist 
 chemical tools for rigorously examining the structures of RNA molecules in
  cells and viruses. In addition\, if it were possible to reliably and robu
 stly identify sites with function-related structures in large RNAs\, such 
 discoveries would open up new opportunities for therapeutic targeting of R
 NA using small molecules. This talk will focus on recent progress in our l
 ab with high-resolution RNA structure probing over large scales such that 
 both secondary and tertiary structure elements can be identified and such 
 that these structural data can be used to identify RNA elements likely to 
 have direct and important roles in cellular function and gene regulation. 
 4:00 pm
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