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SUMMARY:Determination of Time Averaged Blood Glucose Concentrations via Tra
 nsient Absorption Microscopy
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20191201T000000
UID:2026-05-04-19-19-00@natsci.colostate.edu
DTSTAMP:20260504T191900
Description:Literature Seminar\nThe successful management of Diabetes Melli
 tus depends on the assessment of long-term blood glucose concentrations. T
 ime dependent fluctuations of blood glucose make it an impractical clinica
 l marker for disease management. The glycated hemoglobin\, HbA1c\, is the 
 standard clinical marker for diabetes monitoring. Current methodologies fo
 r assessing HbA1c content are susceptible to interpatient variability in m
 ean red blood cell (RBC) lifetimes. In order to mitigate the effects of ti
 me dependent factors on diabetes monitoring\, researchers develop a mathem
 atical model for the distribution of HbA1c across individual RBCs in a sam
 ple1. Experimental histograms are generated using transient absorption mic
 roscopy to detect HbA1c content at the single RBC level. By fitting the mo
 del to experimental data\, long-term average blood glucose concentrations 
 are derived independently of the variability of RBC age or short-term gluc
 ose levels. The results of their methodology are compared to a previously 
 determined model2\, and potential sources of error are examined in this ta
 lk.\n1.) Dong\, Pu-Ting\, et al. “Label-Free Quantitation of Glycated He
 moglobin in Single Red Blood Cells by Transient Absorption Microscopy and 
 Phasor Analysis.” Science Advances\, vol. 5\, no. 5\, 10 May 2019. \n2.)
  D. M. Nathan\, H. Turgeon\, S. Regan\, Relationship between glycated hemo
 globin levels\nand mean glucose levels over time. Diabetologia 50\, (2007)
 . 4:00 pm
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