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SUMMARY:Conformations and Dynamics of Protein Molecular Recognition Probed 
 via Infrared Spectroscopy
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20202201T000000
UID:2026-05-15-19-54-42@natsci.colostate.edu
DTSTAMP:20260515T195442
Description:About the Seminar:\nCharacterization of protein molecular recog
 nition is challenged by both the spatial heterogeneity of proteins and the
  rapid interconversion of potentially important conformational states. Our
  group takes advantage of the potential for high temporal and spatial reso
 lution provided by linear and two-dimensional infrared spectroscopy in com
 bination with the spectral selectivity afforded by site-specific incorpora
 tion of vibrational reporter groups to characterize local environments in 
 proteins. I will share several vignettes about our application of this app
 roach toward understanding the molecular recognition of protein systems wi
 th diverse roles in biology: Src homology 3 domain and proline-rich motifs
 \, cytochrome P450cam and putidaredoxin\, and plastocyanin and cytochrome 
 f. Our studies resolve rapid dynamics at specific locations in the protein
 s and implicate their importance to protein function.\nAbout the Speaker:\
 nMegan Thielges received her B.S. at Arizona State University (Tempe\, AZ)
  in 2003. She completed graduate training in biophysics at The Scripps Res
 earch Institute (La Jolla\, CA) where she earned a Ph.D. under the directi
 on of Professor Floyd E. Romesberg in 2009. She went on to pursue postdoct
 oral research with Professor Michael D. Fayer at Stanford University (Stan
 ford\, CA). In 2012 she joined the faculty at IU where she is currently an
  associate professor in the Department of Chemistry. The Thielges group fo
 cuses on understanding the role of protein conformations and dynamics in t
 heir function by applying linear and multidimensional infrared spectroscop
 y in combination with protein labeling. 4:00 pm
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