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SUMMARY:Transformation Mechanisms of an Antibacterial by Birnessite
LOCATION:Chemsitry A101
TZID:America/Denver
DTSTART:20211020T160000
UID:2026-04-24-11-53-16@natsci.colostate.edu
DTSTAMP:20260424T115316
Description:Literature Seminar:\n\nOxytetracycline\, an antibacterial medic
 ation\, can enter the agricultural system inadvertantly via human or anima
 l waste in the form of manure\, biosolids\, and crop irrigation with recla
 imed water. Overexposure to the medication and functionally similar metabo
 lites can increase bacterial resistance. Thus\, it is important to underst
 and the processes that control the fate and transport of antibacterials in
  agroecosystems. Birnessite\, a naturally occuring manganese oxide mineral
 \, is a strong oxidant. Previous studies have shown that birnessite is cap
 able of oxidizing oxytetracycline\, but failed to study this reaction over
  a period longer than two days. It was also previously believed that the r
 esulting reductive dissolution had negligible effects on the mineral’s o
 xidative ability. Liquid chromatography high resolution mass spectrometry 
 (LC-HRMS) is typically used to study metabolites in solution\, but cannot 
 be used to study the mineral surface. X-ray photoelectron spectroscopy (XP
 S) fills this gap in knowledge as a surface sensitive technique as will be
  discussed in this talk. By combining results of these two methods\, Karpo
 v et al. (2018) suggest that previously defined oxidized metabolites of ox
 ytetracyline oxidize further through interactions with the birnessite surf
 ace\, and that the resulting reductive dissolution of the mineral increase
 s its oxidative ability. By applying the knowledge gained in this study\, 
 we can better understand the fate and transport of oxytetracycline within 
 agroecosystems. Future studies should focus on elucidating how birnessite 
 may oxidize oxytetracycline and other phamaceuticals under natural conditi
 ons to account for variation in soil pH\, and impact of competing reaction
 s.\n\nKarpov\, M.\; Seiwert\, B.\; Mordehay\, V.\; Reemtsma\, T.\; Polubes
 ova\, T.\; Chefetz\, B. Transformation of Oxytetracycline by Redox-Active 
 Fe(III)- and Mn(IV)-Containing Minerals: Processes and Mechanisms. Water R
 es. 2018\, 145\, 136–145. https://doi.org/10.1016/j.watres.2018.08.015. 
 4:00 pm
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