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SUMMARY:Recent Advances in Fe-Catalyzed Radical Cascades/Cross-Couplings
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20220207T160000
UID:2026-05-02-06-07-12@natsci.colostate.edu
DTSTAMP:20260502T060712
Description:About the Seminar:\n\nDespite advances in high-throughput scree
 ning methods leading to a surge in the discovery of catalytic reactions\, 
 our knowledge of the molecular-level interactions in the rate- and selecti
 vity-determining steps of catalytic reactions\, especially those involving
  highly unstable and reactive open-shell intermediates\, is rudimentary. T
 hese knowledge gaps prevent control\, suppression or enhancement\, of comp
 eting reaction channels that can drive development of unprecedented cataly
 tic reactions. In this talk\, I will focus on our use of high-level quantu
 m mechanical calculations\, rigorously calibrated against experimental dat
 a\, to interrogate the mechanisms and to guide the development of new cata
 lysts and reagents for currently sluggish or unselective reactions. In par
 ticular\, I will focus on our use of combined experimental and computation
 al tools to understand and develop new (asymmetric) three-component iron-c
 atalyzed radical cascade/cross-coupling reactions.\n\n&nbsp\;\n\nAbout the
  Speaker:\n\nOsvaldo was born in Mexico and raised in Sacramento\, Califor
 nia. He attended Sacramento City College and transferred to UCLA in 2006 w
 here he worked as an undergraduate at the laboratories of Prof. Houk. He o
 btained his B.S./M.S. in 2009 and completed his Ph.D. in 2012 (UC Davis) u
 nder the guidance of Prof. Tantillo. From 2012-2016 he worked as a postdoc
  with Prof. Kozlowski at the University of Pennsylvania where he used comp
 utational and experimental tools to study transition metal-catalyzed proce
 sses. In 2016 he started his independent position at the University of Mar
 yland College Park as an Assistant Professor\, and then Associate Professo
 r until 2021. In the Fall 2021\, he moved to Texas A&amp\;M University whe
 re his research combined computational and experimental approaches to adva
 nce our understanding of iron- and photo-catalyzed reaction mechanisms.\n\
 nRecent news related to background:\n\nLINK \n\nLINK \n\nLINK  4:00 pm
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