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SUMMARY:Medicinal Inorganic Chemistry: a source of new metal-based prospect
 ive antiparasitic agents
LOCATION:Virtual seminar
TZID:America/Denver
DTSTART:20200201T000000
UID:2026-05-20-02-57-54@natsci.colostate.edu
DTSTAMP:20260520T025754
Description:The diseases produced by trypanosomatid parasites\, like Americ
 an Trypanosomiasis (Chagas disease)\, Human African Trypanosomiasis (sleep
 ing sickness\, HAT) and Leishmaniasis constitute an urgent health problem 
 gathered in the poorest regions of the world. These diseases are highly pr
 evalent and classified as neglected tropical diseases (NTDs) by the World 
 Health Organization (WHO) due to low historical investment by the pharmace
 utical industry. Current chemotherapy is quite old and shows significant t
 oxicity in the human host. Long treatments and complicated therapeutic reg
 imes are needed. Additionally\, drug resistance development have been obse
 rved.\n\nMedicinal Inorganic Chemistry has emerged as an interesting alter
 native for the development of novel metal-based drug candidates against NT
 Ds. Although in the past\, research on vanadium medicinal chemistry has be
 en mainly focused on improving biodistribution and tolerability of the van
 adium insulin-enhancing core or on the development of antitumoral drugs\, 
 more recently\, vanadium compounds were proposed by us for the treatment o
 f diseases caused by parasites. In particular\, searching for prospective 
 vanadium-based drugs for the treatment of Chagas disease\, our group has d
 eveloped different series of structurally related homoleptic and heterolep
 tic oxidovanadium compounds using the strategy of coordinating bioactive l
 igands to the vanadium core. Results of stability in biological medium\, a
 ctivity against the three forms of T. cruzi life cycle\, selectivity towar
 ds the parasite using VERO cells as mammalian cell model and metallomics i
 n the parasite of the compounds will be presented and discussed. 4:00 pm
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