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SUMMARY:Investigating Electrostatic Mechanisms of Lipid Bilayer Membrane St
 ructure and Function
LOCATION:Virtual Seminar
TZID:America/Denver
DTSTART:20200201T000000
UID:2026-05-18-06-56-53@natsci.colostate.edu
DTSTAMP:20260518T065653
Description:Lipid bilayer membranes are complex\, dynamic\, and functional 
 structures composed of a wide diversity of lipids\, proteins\, small molec
 ules\, and water organized in heterogeneous domains through noncovalent in
 teractions. The structure and motion of these molecules generate large ele
 ctric fields within the interior of the membrane that are critical to memb
 rane structure and function. Here\, we describe how vibrational spectrosco
 py of unnatural nitrile chromophores places throughout the membrane struct
 ure is used to measure electrostatic fields in peptides intercalated in fr
 ee-standing lipid bilayer membranes of increasing chemical complexity. In 
 combination with electrodynamics simulations\, these experiments highlight
  how common small molecules such as cholesterol dramatically affect membra
 ne structure and dynamics through large changes to membrane electric field
 s. 4:00 pm
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