BEGIN:VCALENDAR VERSION:2.0 PRODID:-//ZContent.net//ZapCalLib 1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT SUMMARY:Structural analysis and conformational dynamics of the SARS-CoV-2 r eplication–transcription complex LOCATION:Virtual TZID:America/Denver DTSTART:20211104T160000 UID:2026-04-30-16-23-35@natsci.colostate.edu DTSTAMP:20260430T162335 Description:About the Seminar:\n\nThe SARS-CoV-2 genome is replicated and t ranscribed by its RNA-dependent RNA polymerase\, nsp12\, along with severa l accessary cofactors\, together known as the replication–transcription complex.  Helicase nsp13 is one of the cofactors that is essential for vi ral replication.  Structural analyses of the SARS-CoV-2 replication–tra nscription complex revealed that nsp12 stably binds to two copies of nsp13 \, but the role of the two nsp13 molecules as well as how they are coupled to the polymerase during viral genome replication are less clear.  In th is presentation\, I will talk about how a combination of cryo-electron mic roscopy and molecular dynamics simulation provided evidence of an unexpect ed allosteric regulatory mechanism that couples the helicase and polymeras e during SARS-CoV-2 genome replication.\n\n \;\n\nAbout the Speaker:\n \nQi Wang holds a B.S. in physical chemistry from Peking University and a Ph.D. in biophysics from Cornell University. After he completed his postd octoral training in the laboratory of John Kuriyan at U.C. Berkeley\, Qi W ang joined D.E. Shaw Research as a research scientist. Qi’s research int erests include studying structure and function of enzymes on membranes\, a llosteric regulation of protein by small molecules and RNA/DNA remodeling by protein complexes.\n\n \;\n\nJoin Zoom Meeting\nhttps://zoom.us/j/9 4537157545?pwd=b1NuYkRNcCtGK1A3OWxITWVmTm0xdz09\n\nMeeting ID: 945 3715 75 45\nPasscode: 635287\n\nJoin by SIP\n94537157545@zoomcrc.com\n\n \; 4: 00 pm END:VEVENT END:VCALENDAR