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SUMMARY:Reaction Monitoring and Active Site Studies of Copper-MOF Catalyzed
  NO Release from S-Nitrosoglutathione
LOCATION:Virtual Seminar
TZID:America/Denver
DTSTART:20210223T160000
UID:2026-04-21-15-04-00@natsci.colostate.edu
DTSTAMP:20260421T150400
Description:Research Seminar\n\nCatalytic generation of nitric oxide (NO) a
 t material surfaces improves implanted medical device performance. Devices
  containing the metal-organic framework (MOF) [(Cu4Cl)3–(BTTri)8] (CuBTT
 ri) catalyze NO release from the endogenous tripeptide S-Nitrosoglutathion
 e (GSNO). MOFs are hybrid inorganic-organic materials that are promising h
 eterogeneous catalysts due to their tunability\, well-defined geometry\, p
 orosity\, and high surface area. We have developed a method using 1H nucle
 ar magnetic resonance (NMR) spectroscopy and a nitric oxide analyzer to qu
 antitatively monitor all reactants and products for GSNO to NO conversion 
 in real time directly in H2O. The GSNO to NO release reaction monitoring m
 ethod yields the full reaction stoichiometry\, CuBTTri catalyst dependence
  on added thiol\, and location / number of catalytically active Cu sites i
 n CuBTTri. Comparing CuBTTri particle size to the reaction rate reveals th
 at GSNO to NO conversion catalysis is confined to CuBTTri particle exterio
 r surfaces and that no intrapore Cu sites are catalytically active. Cyanid
 e catalyst poisoning shows that catalysis is caused by a single type of Cu
  site. Based on infrared spectroscopic analysis of cyanide-poisoned CuBTTr
 i\, one active Cu site binds 3 equivalents of cyanide. Size-selective pois
 oning using 3\,3′\,3″-phosphanetriyltris trisodium salt was employed t
 o count the catalytically active\, exterior surface Cu sites and calculate
  a normalized catalyst turnover frequency.\n\nZoom Link\n\nMeeting ID:980 
 8740 7340 4:00 pm
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