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SUMMARY:Amination of Unactivated Hydrocarbons Via an Activation-Release Pro
 tocol
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20194101T000000
UID:2026-04-06-04-54-18@natsci.colostate.edu
DTSTAMP:20260406T045418
Description:Research Seminar Abstract\n\nCompounds containing bonds with co
 mbinations of boron\, silicon\, and tin are attractive main group element 
 transfer reagents. These bonds are activated via a nucleophilic attack tha
 t facilitates the release of one of the bonded main group moieties with en
 hanced nucleophilicity towards unactivated electrophiles. We wondered if t
 his interesting reactivity platform could be generalized to exploit new bo
 nd transformations\, such as amination. Amines are ubiquitous in natural p
 roducts and pharmaceuticals such as Flunarizine\, Naftifin\, and Triprolid
 ine. Since amines can act as both a hydrogen bond acceptor and donor\, the
 y are often key contributors in drug-receptor interactions. Additionally\,
  incorporating amines in drugs can aid in increasing the basicity and solu
 bility of the molecule. Due to the importance of amines\, the development 
 of simple methods to directly install amines are in high demand. Current m
 ethods to incorporate amines into molecular scaffolds involve transition m
 etal catalysis and often require activated or prefunctionalized starting m
 aterials. A method that installs amines from unactivated substrates\, such
  as allylic alcohols\, would be a significant advancement to the field. Th
 is can be envisioned by exploiting the innate reactivity of an allylic alc
 ohol\, combined with an aminating reagent that facilitates amine bond form
 ation when activated. 4:00 pm
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