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SUMMARY:Activity-based Ratiometric FRET Probe Reveals Oncogene-Driven Chang
 es in Labile Copper Pools Induced by Altered Glutathione Metabolism
LOCATION:Virtual Seminar
TZID:America/Denver
DTSTART:20201104T160000
UID:2026-04-23-00-50-47@natsci.colostate.edu
DTSTAMP:20260423T005047
Description:Literature Seminar\n\nCellular labile copper(I) as dynamic and 
 loosely bound Cu(I) stores play an important role in cell signaling. Curre
 nt fluorescent has the inconsistency issue in qualitative measurement acro
 ss different samples due to the heterogeneity between cells. The new ratio
 metric Förster Resonance Energy Transfer (FRET) probe\, FRET Copper Probe
 -1(FCP-1)\, is developed with a self-calibration nature in the hope to min
 imize interference from heterogeneity between cell samples. The FCP-1 is u
 sed in cellular labile copper change detection driven by oncogenes. As a s
 ide control group\, a Turn-On probe\, CF4\, is used side by side with the 
 FCP-1 in the same measurements. Analysis based on the data supplied by the
  research shows there isn’t a significant difference between the new FCP
 -1 probe and the Turn-On probe\, CF4\, in dealing with the heterogeneity b
 etween cells. Further research in other heterogeneous cellular environment
 s like zebrafish brain tissue or lung cancer immortal cell A549 is require
 d to provide insight into the comparison between the new FRET-based probe 
 and the Turn-On probe.\n\nLink to Seminar: TBA 4:00 pm
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