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SUMMARY:Searching for Selective Catalytic Reactions in Complex Molecular En
 vironments
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20201201T000000
UID:2026-04-30-08-02-37@natsci.colostate.edu
DTSTAMP:20260430T080237
Description:About the Seminar:\nThis lecture will describe recent developme
 nts in our efforts to develop catalysts for asymmetric reactions\, in part
 icular for the preparation of densely functionalized\, stereochemically co
 mplex structures.  Over time\, our foci have been on enantioselectivity\
 , site-selectivity and chemoselectivity.  In much of our current work\, w
 e are studying issues of enantioselectivity as a prelude to extrapolation 
 of catalysis concepts to more complex molecular settings where multiple i
 ssues are presented in a singular substrate.  Some of our substrates are 
 complex natural products.  Moreover\, we continuously examine an interpla
 y between screening of catalyst libraries and more hypothesis-driven exper
 iments that emerge from screening results.  Some of the mechanistic para
 digms\, and their associated ambiguities\, will figure strongly in the lec
 ture.\nAbout the Speaker:\nScott J. Miller was born on December 11\, 1966 
 in Buffalo\, NY. He received his B.A. (1989)\, M.A. (1989) and Ph.D. (1994
 ) from Harvard University\, where he worked with David Evans as a National
  Science Foundation Predoctoral Fellow.  Subsequently\, he traveled to th
 e California Institute of Technology where he was a National Science Found
 ation Postdoctoral Fellow with Robert Grubbs until 1996. For the following
  decade\, he was a member of the faculty at Boston College\, until joining
  the faculty at Yale University in 2006.  In 2008\, he was appointed as t
 he Irénée duPont Professor of Chemistry.\nProfessor Miller’s research 
 program focuses on catalysis. His group employs strategies that include ca
 talyst design\, the development of techniques for catalyst screening\, and
  the application of new catalysts to the preparation of biologically activ
 e agents.  Three current interests are (a) the selective functionalizatio
 n of complex molecules\, (b) the exploration of analogies between syntheti
 c catalysts and enzymes\, (c) the discovery of effective antibiotics despi
 te increasing resistance\, and (d) the engineering of the biosynthetic app
 aratus for nonextant bond-formation.\nScott Miller’s awards and honors i
 nclude: National Science Foundation CAREER Award (1999)\, Alfred P. Sloan 
 Research Fellowship (2000)\, Camille Dreyfus Teacher-Scholar Award (2000)\
 , Arthur C. Cope Scholar Award of the American Chemical Society (2004)\, Y
 oshimasa Hirata Memorial Gold Medal of Nagoya University (2009)\, National
  Institutes of Health MERIT Award (2011)\, Fellow of the American Associat
 ion for the Advancement of Science (2012)\, American Chemical Society Awar
 d for Creative Work in Synthetic Organic Chemistry (2016)\, Member\, Ameri
 can Academy of Arts and Sciences (2016)\, Max Tishler Prize\, Harvard Univ
 ersity (2017)\, Fellow of the American Chemical Society (2018).\nProfessor
  Miller has served in number of capacities for public and private organiza
 tions.  For example\, he recently completed a term on the National Instit
 ute of General Medical Sciences Advisory Council\, convened by the Directo
 r of the National Institutes of Health.  He now serves as Editor-in-Chief
  of The Journal of Organic Chemistry. 4:00 pm
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