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SUMMARY:BRØNSTED BASE-CATALYZED METHOD TO  α-SELECTIVELY DEUTERATE  STYRE
 NE DERIVATIVES
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20193201T000000
UID:2026-04-22-16-18-00@natsci.colostate.edu
DTSTAMP:20260422T161800
Description:Styrenes are widely utilized synthetic precursors for a range o
 f polymerization and hydro-/dual-functionalization reactions. Chemists com
 monly probe the mechanism of these reactions by selectively incorporating 
 deuterium onto the vinyl positions of the styrene derivative. There have b
 een several catalytic methods reported to either completely label the viny
 l group or selectively label the β-position with deuterium. An α-selecti
 ve variant\, however\, has yet to be developed. This seminar will present 
 a new Brønsted base-catalyzed approach to label the α-position with 100%
  α:β selectively. Improving access to these useful isotopomers will have
  significant applications for their use in mechanistic studies and as prec
 ursors to medicinally-relevant chiral deuterated benzylic stereocenters\, 
 positions frequently prone to in vivo metabolic oxidation.  4:00 pm
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