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SUMMARY:Electrochemical Aptamer-Based (EAB) Biosensors for Point-of-Care Di
 agnostics
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20211020T160000
UID:2026-04-29-00-42-03@natsci.colostate.edu
DTSTAMP:20260429T004203
Description:Literature Seminar:\n\nPoint-of-care testing (POCT) is crucial 
 for rapid detection of analytes for non-communicable and communicable dise
 ases because it allows for better disease management and treatment.  Esta
 blished lab-based techniques for quantification of desired analytes are ti
 me and resource expensive. Electrochemical biosensors are a rapid and chea
 p alternative while maintaining sensitivity and selectivity in numerous bi
 ological fluids. Currently\, antibodies are the most common biological sen
 sing element applied in affinity-based electrochemical biosensors\, but th
 e use of aptamers --single stranded oligonucleotides-- in biorecognition a
 ppears to be a growing trend due to superior stability\, selectivity\, and
  sensitivity. This growth can also be attributed to the introduction of SE
 LEX (Systematic Evolution of Ligands by EXponential enrichment)\, a method
  used to obtain more specific aptamers for different target molecules.  I
 n an electrochemical aptamer-based (EAB) sensor\, the aptamer is anchored 
 to the electrode at one terminus\, and a redox reporter is attached to oth
 er terminus. The presence of target creates binding-induced conformational
  change of the aptamer\, thus changing the measurable electrochemical sign
 al. Through voltammetry techniques\, one can measure the change of electro
 n transfer rate that occurs between the attached redox reporter and the in
 terrogating electrode surface in target bound and unbound states. The sign
 al change percentage is plotted against target concentration allowing for 
 quantification of analyte concentration in a sample. The implementation of
  EAB sensors can allow for the rapid and cheap detection of target analyte
 s for POCT. 4:00 pm
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