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SUMMARY:Increasing Chalcogen Bond Strength via Oxidation State: Application
 s to Anion Binding and Transport
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20211005T160000
UID:2026-04-29-13-08-46@natsci.colostate.edu
DTSTAMP:20260429T130846
Description:Literature Seminar\nChalcogen bonding is a non-covalent interac
 tion involving a Lewis acidic chalcogen (S\, Se\, Te) atom and a Lewis bas
 ic nucleophile that largely involves electrostatics\, charge-transfer\, an
 d dispersion as well as reduction of repulsion to form an interaction that
  is generally stronger than hydrogen bonding (15-20 kcal mol-1).1 Non-cov
 alent interactions are key functions of ion-transport across biological me
 mbranes\, which are regulated by embedded pumps\, channels\, and carriers 
 that maintain ion and pH homeostasis and dysregulation these mechanisms ca
 n result from genetic diseases such as cystic fibrosis.2 Synthetic carrie
 rs that utilize tunable non-covalent interactions allow for treatment of s
 uch diseases as well as targeted drug delivery. In this presentation\, I w
 ill share how Gabbaï and Zhou leveraged the non-covalent chalcogen bond f
 or transporting chloride ions through phospholipid bilayers using six Tell
 urium complexes with tunable Lewis acidity.3 Through this Lewis acidity\,
  chalcogen bonding was quantified via density functional theory (DFT) meth
 ods and through overall ion transport. Their methods (experimental and the
 oretical) will be discussed as well as the future outlook for chalcogen bo
 nding applications in anion transport.\n(1)        Vogel\, L.\; Wonn
 er\, P.\; Huber\, S. M. Chalcogen Bonding: An Overview. Angewandte Chemie
  International Edition 2019\, 58 (7)\, 1880–1891. https://doi.org/10
 .1002/anie.201809432.\n\n(2)        Gale\, P. A.\; Davis\, J. T.\; Q
 uesada\, R. Anion Transport and Supramolecular Medicinal Chemistry. Chem.
  Soc. Rev. 2017\, 46 (9)\, 2497–2519. https://doi.org/10.1039/C7CS00
 159B.\n\n(3)        Zhou\, B.\; Gabbaï\, F. P. Redox-Controlled Cha
 lcogen-Bonding at Tellurium: Impact on Lewis Acidity and Chloride Anion Tr
 ansport Properties. Chem. Sci. 2020\, 11 (28)\, 7495–7500. https://
 doi.org/10.1039/D0SC02872J. 4:00 pm
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