BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//ZContent.net//ZapCalLib 1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
SUMMARY:Cu-dependent CTR1 oligomerization and Cu-uptake regulation
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20220414T160000
UID:2026-05-05-21-53-55@natsci.colostate.edu
DTSTAMP:20260505T215355
Description:About the Seminar:\n\nCopper enters cells through pores formed 
 by trimeric Human copper transporter 1 (hCTR1). Elevated Cu induces clathr
 in-dependent endocytosis of hCTR1 and decreases the hCTR1 surface abundanc
 e by half.  However\, it remains unclear how cells minimize the Cu-uptake
  activity of the remaining surface hCTR1.  This study examined the oligom
 eric states of hCTR1 complexes in fixed COS7 cells using super-resolution 
 localization microscopy and single-molecule oligomeric state quantificatio
 n assay.  We found that the hCTR1 on the plasma membrane exists dominantl
 y in the trimeric form (~80%) under basal conditions and shifts to monomer
 ic states (~50%) under Cu stressed conditions. This finding suggests cells
  may further modulate the oligomer distributions of the surface hCTR1 to r
 educe cellular Cu-uptake and provide insight into the hCTR1 transport mech
 anism.\n\nAbout the Speaker:\n\nTai-Yen earned his B.S. (2002) and M.S. (2
 004) in Chemistry from National Tsing Hua University and a Ph.D. (2010) fr
 om Texas A&amp\;M University before pursuing a postdoctoral associate (201
 1-2016) at Cornell University.  Tai-Yen started his independent career as
  an assistant professor of the Department of Chemistry at the University o
 f Houston in 2016. His research focuses on the metal homeostasis in health
 y and diseased neurons using single-molecule techniques. In particular\, h
 is group is interested in the dynamics and mechanisms of protein machinery
  involved in Cu trafficking within/between neurons. His research goal is t
 o understand how metals affect neuronal signaling and cause neurodegenerat
 ive diseases. His work has been recognized with the Maximizing Investigato
 rs\\' Research Award for Early Stage Investigators and a Robert A. Welch F
 oundation grant. Besides research\, Tai-Yen enjoys and enthusiastically pa
 rticipates in multiple educational activities. In recognition of his class
 room teaching and laboratory mentorship\, Tai-Yen received the College\\'s
  highly competitive John C. Butler Excellence in Teaching Award in 2021. 4
 :00 pm
END:VEVENT
END:VCALENDAR