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SUMMARY:Copper Catalyzed C-H Functionalization: Method Development via Enab
 ling Intermediates
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20240416T160000
UID:2026-05-03-16-00-40@natsci.colostate.edu
DTSTAMP:20260503T160040
Description:About the Seminar:\n\nCatalytic C-H functionalization offers th
 e promise of atom economical introduction of molecular diversity into orga
 nic molecules by direct transformation of C-H bonds to C-C\, C-N\, or C-O 
 bonds. Compared to more traditional approaches that involve functional gro
 up manipulations\, the direct utilization of C-H bonds in synthesis can mi
 nimize chemical steps\, economic cost\, and environmental impact.\n\nEmplo
 ying a copper-based catalyst system\, we have employed both organoazides a
 s well as alkyl- and arylamines in sp3 C-H amination. Experimental and the
 oretical insights into the mechanism of C-H amination by our b-diketiminat
 o copper(I) catalyst system have revealed three different classes of H-ato
 m abstracting species that break sp3 C-H bonds in substrates R-H to afford
  radicals R·. Combining these mechanistic findings with efficient radical
  capture by copper(II) intermediates has resulted in a range of new cataly
 tic C-H functionalization reactions that result in C-N\, C-O\, and C-C bon
 d formation. For instance\, synthetic investigation of these copper(II) in
 termediates results in novel examples of copper(II) aryl\, alkynyl\, alken
 yl\, and methyl complexes that participate in C-C bond forming reactions.\
 n\n&nbsp\;\n\nAbout the Speaker: \n\nTimothy H. Warren was born in 1970 a
 nd raised in Hillside\, Illinois\, a suburb of Chicago.  After earning a 
 B.S. summa cum laude from the University of Illinois at Urbana-Champaign i
 n 1992 where he performed undergraduate research with Prof. Gregory S. Gir
 lolami\, he pursued graduate work with Prof. Richard R. Schrock (2005 Nobe
 l Laureate in Chemistry) at the Massachusetts Institute of Technology and 
 received his Ph.D. in 1997. NSF-NATO and Alexander von Humboldt fellowship
 s supported postdoctoral studies with Prof. Gerhard Erker at the Universit
 y of Münster\, Germany. In 1999\, he began his independent career at Geor
 getown University where he was later named the Richard D. Vorisek Professo
 r of Chemistry and served as department chair and led the Georgetown Envir
 onmental Initiative. In 2021\, he moved to Michigan State University as Ba
 rnett Rosenberg Professor of Chemistry and department chair where he led t
 he recruitment of ten tenure track faculty in 2022 – 2024.\n\nProf. Warr
 en’s research interests include C-H functionalization methods based on o
 rganometallic copper complexes\, molecular electrocatalysts for the interc
 onversion of nitrogen and ammonia as carbon-free fuels\, and synthetic bio
 inorganic chemistry to decode ways that biology communicates using nitric 
 oxide as a molecular messenger. With sustainability in mind\, catalysts de
 veloped by the Warren group involve Earth abundant metals such as copper\,
  or in some cases\, no metals at all.  Prof. Warren served as the chair o
 f the 2019 Inorganic Reaction Mechanisms Gordon Research Conference and a 
 section editor for Comprehensive Organometallic Chemistry IV. He currently
  is the chair of the Organometallic subdivision in the ACS Division of Ino
 rganic Chemistry. 4:00 pm
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