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SUMMARY:Three Musketeers in the Lab: Phosphino Organometallic Complexes of 
 Ir, Os, and Ru (but not only!) in the Fight Against Cancer
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20260310T160000
UID:2026-04-28-12-40-49@natsci.colostate.edu
DTSTAMP:20260428T124049
Description:Abstract:\n\nDespite many excellent medical achievements in the
  field of cancer therapies\, resistance to chemotherapy as well as disease
  relapses remain a huge clinical challenge. One of the strategies in desig
 ning new anticancer therapeutics is the use of compounds based on metal io
 ns surrounded by selected ligands (metal drugs). Different metal centers m
 ay exhibit different coordination geometries and redox capabilities\, whil
 e ligands may additionally exhibit different biological activities. Moreov
 er\, metal ions have a high affinity for biologically important intracellu
 lar thiols\, which may significantly disturb the intracellular redox balan
 ce\, lead to protein and enzyme dysfunction\, and even to the accumulation
  of lipid peroxides inside the cell\, which may result in cell death via t
 he so-called ferroptosis.\n\nThe main objectives of the presented project 
 are the design\, synthesis\, and characterization of Ru(II)\, Ir(III)\, Os
 (II) mononuclear as well as heteronuclear Ru(II)/Cu(II)\, Ir(III)/Cu(II) c
 omplexes leading to ferroptosis of drug-resistant cancer cells. We tried t
 o better understand the stability and behavior of the proposed compounds i
 n biological systems (cells\, spheroids\, zebrafish model\, fig. 1)\, and 
 their interaction with high and low molecular biomolecules (e.g.\, ctDNA\,
  plasmid DNA\, 9-ethylguanine\, 9-methyladenin\, human albumins\, nicotina
 mide adenine dinucleotide\, cysteine\, glutathione\, and ascorbic acid) mi
 micking natural\, biological environment. In addition\, to improve the eff
 iciency and reliability of drug delivery to the tumor site\, nanoparticle 
 systems for drug delivery (e.g.\, liposome\, bilosomes\, micelle\, magneti
 c micelle) have been developed.\n\nSpeaker Bio:\n\nDr hab. Urszula K. Koma
 rnicka is an Associate Professor from Poland\, affiliated with the Departm
 ent of Biological and Medicinal Chemistry at the University of Wrocław wh
 ere She received her PhD in Inorganic Chemistry in 2016. Her research focu
 ses on medicinal inorganic chemistry\, especially organometallic phosphine
  complexes\, their anticancer mechanisms (including ferroptosis induction)
 \, and their interactions with biomolecules.\n\nHer international scientif
 ic experience includes several postdoctoral stays in Italy: at ICMATE – 
 Institute of Condensed Matter Chemistry and Energy Technologies in Padova\
 , where she worked on phosphine ligands and copper(I) complexes\, and at t
 he Department of Pharmaceutical and Pharmacological Sciences\, University 
 of Padova\, where she focused on biological assays and cell culture studie
 s. She subsequently undertook a research stay at Colorado State University
  (USA) working on phosphino-vanadium complexes and completed additional re
 search work at Palacký University Olomouc (Czech Republic).\n\nDr. Komarn
 icka leads competitive NCN and NAWA-funded research projects\, collaborate
 s internationally\, and has authored numerous publications in high-impact 
 journals. She serves on editorial boards such as Frontiers in Chemical Bio
 logy\, Pharmaceuticals\, and the Early Career Board of Coordination Chemis
 try Reviews. She is also an experienced academic mentor who has supervised
  many bachelor’s\, master’s\, and PhD students\, and is an active invi
 ted speaker at international conferences. 4:00 pm
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