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SUMMARY:Transition Metal Catalyzed Ring Formation Reactions and a Mild Aren
 e Hydrogenation Method
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20260330T160000
UID:2026-05-05-01-04-08@natsci.colostate.edu
DTSTAMP:20260505T010408
Description:Seminar Abstract:\n\nMany natural products and pharmaceuticals 
 have complex polycyclic structures that present synthetic challenges. Ther
 e are many powerful reactions (Diels-Alder\, Pauson-Khand\, Grubbs ring-cl
 osing metathesis\, Wender arene-alkene photocycloadditions\, and others)\,
  but new ring formations are always in high demand. For the last 20 years\
 , my group has pioneered in the development of more than twenty new Rh-cat
 alyzed ring-forming reactions. Applications of these new reactions in tota
 l synthesis has been demonstrated by us and by other research groups. I wi
 ll discuss the development and mechanistic elaboration of several transiti
 on metal-catalyzed reactions to construct difficult seven- and eight-membe
 red rings\, as well as applications of these reactions for the synthesis o
 f natural products. In the second part of the talk\, I will describe our r
 ecent discovery of a new mild arene hydrogenation reaction that occurs at 
 room temperature under 1 atmosphere of hydrogen gas\, and this will provid
 e a convenient approach to reach a variety of useful saturated six-membere
 d rings in synthesis.\n\nSpeaker Bio:\n\nZhi-Xiang Yu is a Chang-Jiang Pro
 fessor of Chemistry at Peking University\, where he leads the Theoretical 
 and Synthetic Organic Chemistry Laboratory. His research integrates comput
 ational chemistry and organic synthesis to understand reaction mechanisms\
 , develop new catalytic reactions\, and synthesize natural products and ph
 armaceutical molecules. Born in Ezhou\, Hubei Province\, China\, he earned
  his B.S. from Wuhan University and his M.S. from Peking University befo
 re completing his Ph.D. in computational chemistry at Hong Kong University
  of Science and Technology under the supervision of Yun-Dong Wu. He carri
 ed out postdoctoral research at University of California\, Los Angeles wi
 th K. N. Houk and M. Mascal before joining the faculty at Peking Univers
 ity in 2004. Yu has also been a visiting scholar at Harvard University\, D
 uke University\, University of British Columbia\, and California Institute
  of Technology\, and he is a Fellow of the Royal Society of Chemistry. 4:0
 0 pm
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