About the Seminar:

The SARS-CoV-2 genome is replicated and transcribed by its RNA-dependent RNA polymerase, nsp12, along with several accessary cofactors, together known as the replication–transcription complex.  Helicase nsp13 is one of the cofactors that is essential for viral replication.  Structural analyses of the SARS-CoV-2 replication–transcription complex revealed that nsp12 stably binds to two copies of nsp13, but the role of the two nsp13 molecules as well as how they are coupled to the polymerase during viral genome replication are less clear.  In this presentation, I will talk about how a combination of cryo-electron microscopy and molecular dynamics simulation provided evidence of an unexpected allosteric regulatory mechanism that couples the helicase and polymerase during SARS-CoV-2 genome replication.

About the Speaker:

Qi Wang holds a B.S. in physical chemistry from Peking University and a Ph.D. in biophysics from Cornell University. After he completed his postdoctoral training in the laboratory of John Kuriyan at U.C. Berkeley, Qi Wang joined D.E. Shaw Research as a research scientist. Qi’s research interests include studying structure and function of enzymes on membranes, allosteric regulation of protein by small molecules and RNA/DNA remodeling by protein complexes.

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