Nancy Levinger Professor and University Distinguished Teaching Scholar

Office: Chemistry C205

Phone: (970) 491-1331

Website: https://levingerlab.colostate.edu/

Curriculum Vitae: http://levingerlab.colostate.edu/wp-content/uploads/2018/04/NEL-CV-2018-short.pdf

Google Scholar: https://scholar.google.com/scholar?hl=en&as_sdt=0%2C6&q=nancy+levinger&btnG=&oq=nancy

Education

  • Ph.D., University of Colorado
  • B.A., Northwestern University, Integrated Science and Physics

About

Research in the Levinger group has two main thrusts: dynamics of molecules in confined environments and fundamental processes governing cell cryopreservation. 

Dynamics in nanoconfinement
For many years, we have explored the role of nanoconfinement on the structure and dynamics of molecules in the condensed phase.  We are particularly interested in learning how the heterogeneous environment at liquid interfaces influences molecules residing there and the chemistry that then occurs. We have used reverse micelles as a model system to prepare well defined liquid droplets on the nanoscale. Reverse micelles form in ternary or higher order mixtures of polar, nonpolar and amphiphilic molecules.  Most often, the polar solvent used is water but we have also explored a range of non-aqueous polar solvents for these systems including ordinary organic solvents such as ethylene glycol, DMSO, formamide, etc. as well as novel room temperature ionic liquids.  We have utilized the workhorse surfactant, AOT, for many of our studies as well as phospholipids, cationic and nonionic surfactants.  We have utilized a range of experimental techniques, including steady state and ultrafast time-resolved laser spectroscopies, 1D, 2D and multinuclear NMR, and neutron scattering.
 
Fundamental processes governing cell cryopreservation
A new thrust for the Levinger group explores how and why some cells can withstand freezing conditions that would normally kill them. We are embarking on a project to explore the role of permeating cryopreservation agents, e.g., glycerol, DMSO.  This project aims to uncover how these small molecules cross cell membranes, where they reside in cells and how they protect cells from cold. 

Publications

Nanoconfinement Raises the Energy Barrier to Hydrogen Atom Exchange between Water and GlucoseSam L. Miller, Benjamin Paul Wiebenga-Sanford, Christopher D. Rithner, E E. Levinger Journal of Physical Chemistry B, American Chemical Society.
Celebrating Debbie C. Crans on the event of her ACS Award for Distinguished Service in the Advancement of Inorganic Chemistry, 2019Nancy E. Levinger, Bharat Baruah JOURNAL OF INORGANIC BIOCHEMISTRY, 2020.
Journal of inorganic biochemistry - Crans special issue PrefaceNancy E. Levinger, Bharat Baruah JOURNAL OF INORGANIC BIOCHEMISTRY, 2020.
Coordination Chemistry of a Controlled Burst of Zn2+ in Bulk Aqueous and Nanosized Water Droplets with a Zincon ChelatorCheryle Nicole Beuning, Noah E. Barkley, Prem N. Basa, Shawn C. Burdette, Nancy E. Levinger, Debbie C. Crans INORGANIC CHEMISTRY, 1, 2020.
Coordination Chemistry of a Controlled Burst of Zn2+ in Bulk Aqueous and Nanosized Water Droplets with a Zincon ChelatorCheryle Nicole Beuning, Noah E. Barkley, Prem N. Basa, Shawn C. Burdette, Nancy E. Levinger, Debbie C. Crans Inorganic Chemistry , 1, 2020.
Photophysical characterization of metal ion burst: Photolytic decarboxylation of Zn(II)-nitrilotriacetate cage to release a burst of Zn(II) ions and retrieval by Zincon within AOT-isooctane reverse micellesCheryle Nicole Beuning, Noah E. Barkley, Prem N. Basa, Shawn C. Burdette, Nancy E. Levinger, Debbie C. Crans Langmuir.
ConfChem Conference on Mathematics in Undergraduate Chemistry Instruction: Applied Mathematics for Chemistry MajorsRachel Augusta Neville, Patrick D. Shipman, Nancy E. Levinger, Amber Teresa Krummel JOURNAL OF CHEMICAL EDUCATION, 8, 2018.
Sweet Confinement: Glucose and Carbohydrate Osmolytes in Reverse MicellesBenjamin Paul Wiebenga-Sanford, Jack B. Washington, Brett Cosgrove, Eduardo F. Palomares, Derrick A. Vasquez, Christopher D. Rithner, Nancy E. Levinger JOURNAL OF PHYSICAL CHEMISTRY B, 41, 2018.
Sweet confinement: Interactions of sugars confined at molecular interfacesNancy E. Levinger, Benjamin Paul Wiebenga-Sanford ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018.
Tribute to Veronica VaidaD. James Donaldson, Joseph S. Francisco, Vicki H. Grassian, Russell J. Hemley, David M. Jonas, Kenneth R. Leopold, Nancy E. Levinger JOURNAL OF PHYSICAL CHEMISTRY A, 5, 2018.