About the seminar:

Electrochemical biosensing platforms offer an affordable alternative to centralized diagnostic screening methods. However, current electrochemical detection assays do not offer the same limits of detection as industry standards (i.e. ELISA). In recent years, Laser-Induced Graphene (LIG) electrodes have shown superior electrochemical performance to other commonly used carbon electrodes often employed in such devices due to their low fabrication cost. This superiority is generally attributed to the large electroactive surface area of LIG. Yet, conventional electrochemical analytical approaches such as the Randles- Ševčík equation assume diffusion limited mass transport and uniform electrode geometry, making them incomplete descriptions of the heterogeneous porous regimes present in LIG. This shortcoming in analysis limits our ability to distinguish apparent electroactive surface area from contributions of pore structure, analyte depletion, and limited diffusion. Developing more comprehensive analytical frameworks is crucial to describe LIG’s structure-function relationship and guide its fabrication/integration into biosensing devices. Improved electrochemical characterization may drive performance closer to industry-standard detection limits, enabling the integration of LIG into the development of next-generation scalable electrochemical biosensing assays.