Debbie Crans

Debbie CransProfessor
Office: Chemistry C301
Phone: 970-491-7635
Website: http://wp.natsci.colostate.edu/crans
Education: Ph.D., Harvard University
Email: Debbie.Crans@colostate.edu

My research is focused on bioinorganic, bioorganic, and physical organic chemistries. Our group is interested in the prominence of metals in medicine specifically vanadium and other transition metals and their ions. We utilize lipid and micro-emulsion interfaces to understand drug uptake across membranes. We study the coordination, speciation, and kinetic characterization of metal ion complexes with various biologically relevant ligands such as the amyloid-beta protein which is involved in Alzheimer’s disease. Projects involving menaquinone metabolism and ihibition of electron transport in tuberculosis bacteria are ongoing. We utilize various spectroscopic techniques in characterization of these systems including 1D and non-routine 2D NMR, EPR, UV-vis, fluorescence, and IR. The group has many CSU, US, and international collaborators.

Selected Publications

“Multinuclear NMR studies of aqueous Vanadium-HEDTA Complexes” Xiao Wu, Benjamin J. Peters, Christopher D. Rithner and Debbie C. Crans, Polyhedron, 2015, ASAP. http://dx.doi.org/10.1016/j.poly.2016.01.001

“How Interfaces Affect the Acidity for the Anilinium Ion” Jarukorn Sripradite, Susanne Miller, Michael D. Johnson, Anan Tongraar, and Debbie C. Crans, Chemistry – A European Journal., 2015, 3873-3880.

“Size and shape trump charge in interactions of oxovanadates with self-assembled interfaces: Application of Continuous Shape Measure analysis to the decavanadate anion” Irma Sánchez-Lombardo, Bharat Baruah, Santiago Alvarez, Katarina R. Werst, Nicole A. Segaline, Nancy E. Levinger and Debbie C. Crans, New J. Chem., 2015, ASAP. DOI:10.1039/c5nj01788b.

"Antidiabetic, chemical and physical properties of organic vanadates as presumed transition state inhibitors for phosphatases" Debbie C. Crans, J. Org. Chem., 2015, 80 (24), 11899-11915. http://dx.doi.org/10.1021/acs.joc.5b02229. This article was featured on the cover.

“MenI, a novel menaquinone reductase in Mycobacterium tuberculosis is required for survival in macrophages,” Ashutosh Upadhyay, Fabio Fontes, Mercedes Gonzalez-Juarrero, Michael R. McNeil, Debbie C. Crans, Mary Jackson and Dean C. Crick, ACS Central Science, 2015, 1, 292-302.

“Vanadium-protein complexes: Phosphatase inhibitors favor the trigonal bipyramidal transition state geometries,” Craig C. McLauchlan, Benjamin J. Peters, Gail R. Willsky and Debbie C. Crans, Coord. Chem. Rev., 2015, 301-302, 163-199. The article is featured on the Cover.

“High-frequency and -field electron paramagnetic resonance of vanadium(IV, III, and II) complexes,” Jurek Krzystek, Andrew Ozarowski, Joshua Telser and Debbie C. Crans, Coord. Chem. Rev., 2015, 301-302, 123-133.

“Evaluating transition state structures of vanadium-phosphatase protein complexes using shape analysis,” Irma Sanchez-Lombardo, Santiago Alvarez, Craig C. McLauchlan and Debbie C. Crans, J. Inorg. Biochem., 2015, 147, 153-164.

“NMR crystallography for structural characterization of oxovanadium(V) complexes: Deriving coordination geometry and detecting weakly coordinated ligands at atomic resolution in the solid state,” Mingyue Li, Jenna Yehl, Guangjin Hou, Pabitra B. Chatterjee, Amir Goldbourt, Debbie C. Crans and Tatyana Polenova, Inorg. Chem., 2015, 54, 1363-1374.

“Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis,” Wei Li, Ashutosh Upadhyay, Fabio L. Fontes, E. Jeffrey North, Yuehong Wang, Debbie C. Crans, Anna E. Grzegorzewicz, Victoria Jones, Scott G. Franzblau, Richard E. Lee, Dean C. Crick and Mary Jackson, Antimicrob. Agents  Chemotheraphy201458 (11), 6413-6423.

“Effects of vanadium (III, IV, V)-chlorodipicolinate on glycolysis and antioxidant status in the liver of STZ-induced diabetic rats,” Mingxia Xie, Deliang Chen, Fang Zhang, Gail R. Willsky, Debbie C. Crans and Wenjun Ding, J. Inorg. Biochem., 2014, 136, 47–56.

“Correlation of insulin enhancing properties of vanadium dipicolinate complexes in model membrane systems: Phospholipid langmuir monolayers and AOT reverse micelles,” Audra G. Sostarecz, Ernestas Gaidamauskas, Steve Distin, Sandra J. Bonetti, Nancy E. Levinger and Debbie C. Crans, Chem. Eur. J.201420, 5149-5159.

“Metal speciation in health and medicine represented by iron and vanadium,” Debbie C. Crans, Kellie A. Woll, Kestutis Prusinskas, Michael D. Johnson, and Eugenijjus Norkus, Inorg. Chem., 201352, 12264-12275.  (IC Forum dx.doi.org/10.1021/ic4007873)

“Coordination chemistry may explain pharmacokinetics and clinical response of vanadyl sulfate in type 2 diabetic patients,” Gail R. Willsky, Katherine Halvorson, Michael E. Godzala III, Lai-Har Chi, Mathew Most, Peter Kaszynski, Debbie C. Crans, Allison B. Goldfine and Paul J. Kostnyniak,  Metallomics, 20135, (11) 1491-1502.  (DOI:10.1039/C3MT00162H)

“Solid-to-solid oxidation of a vanadium(IV) to be a vanadium(V) compound:  Chemistry of a sulfur containing siderophore,” Pabitra B. Chatterjee and Debbie C. Crans, Inorg. Chem., 2012, 51, 9144-9146.