About the Seminar:

Though nitrogen-nitrogen bonds are widely present in bioactive compounds and drug molecules, they are difficult to construct due to the inherent nucleophilicity of both nitrogen atoms. Consequently, nitrogen-nitrogen (N−N) bonds are typically integrated via two C−N bond formations. Incorporation of the N−N bond is limited to commercially available hydrazine synthons and remains the most frequently used method in synthesizing N−N bond-containing molecules.  Direct N−N bond construction remains a highly efficient but underutilized method for synthesizing N−N bond-containing molecules.  I propose forming N–N bonds by reacting iron-derived nitrenes with amines. This approach operates via a hydroxylamine precursor for iron-nitrene formation that is amenable to established iron-catalyzed methods