Nickel-catalyzed cross coupling reactions driven by light represent a family of promising new methods to furnish carbon-hetoatom (C-N, C-O, and C-S) bonds which are highly sought after in medicinal and process chemistry, as well as in other fields. The development of a novel C-N bond formation method between aryl halides and amines that proceeds under mild conditions via photo-excitation of a Ni-amine complex with 365 nm light will be described first. Next, we explore the question as to whether the same type of C-N bond forming reactions can proceed via energy transfer from an excited state photocatalyst to a Ni-amine complex, a process which had not been explored mechanistically in dual catalytic (Ni and photocatalyst) reaction systems prior to the work described. In the final section of the talk, an ongoing collaboration with the Johannes Group at AstraZeneca is discussed in which we perform a mechanistic study of their unified C-N, C-O, and C-S coupling methodology, for which we find a reaction pathway to be operative that to our knowledge has not yet been supported experimentally in any dual catalytic system to date.
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