About the Seminar
Over the past few years, our group has utilized photoredox catalysis to access highly-reactive radical intermediates. Our broader aims are centered on utilizing these intermediates to deliver structural motifs that are commonly found in drugs and agrochemicals. This lecture will include recent findings that have enabled us to overcome inherent difficulties in aryl radical reactivity, allowing for the development of highly chemoselective and switchable processes. Importantly, these studies have enabled the development of many other selective processes, including strategies for peptide functionalization and activation of very strong C–F bonds.
About the Speaker
Nate is a Colorado native who started his chemistry career in the Rovis lab at CSU. He earned his PhD in the lab of Dave MacMillan at Princeton, where his thesis work involved the development of enantioselective cycloaddition processes that operate through an oxidative radical-polar crossover mechanism. After graduate school, he was an NIH postdoctoral fellow in the Buchwald lab at MIT, where he developed new catalytic methods for regioselective heterocycle formation. He was also involved in a collaborative project that aimed to study and combat neurodegenerative disease. He started his independent career at Emory in 2014, where his program is focused on the development of new methods for the preparation of pharmaceutically relevant scaffolds, as well as the design of small molecules that alter gene expression.