Research Seminar

MR thermometry would enable powerful biomedical applications with the design of novel cobalt-59 spin-base probes. Yet unrealized is the strong temperature dependence of structure-function relationship between ligand and nuclear spin in various cobalt complexes. Herein, a series of Co-N6 complexes is investigated to understand how to control temperature dependent nuclear spin properties of cobalt-59 by ligand identity. Analyses reveal importance of ligand encapsulation, metal-ligand bond angles, and finite control of temperature sensitivity which build a chemist’s toolbox to designing sensitive thermometric probes.

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