Metal–Organic Framework-based Materials for Localized Generation of Nitric Oxide at Biointerfaces

Research seminar

Nitric oxide (NO) is an endogenously produced molecule that has been demonstrated to aid in the prevention of thrombus formation and promote accelerated wound healing.1,2  Metal–organic frameworks (MOFs) are a class of crystalline materials that consist of organic ligands coordinated to metal centers. Certain copper-based MOFs have demonstrated the ability to enhance the generation of NO from S-nitrosothiols (RSNOs), which occur in blood as physiological NO donors.3 Through integration of certain copper-based MOFs with medically relevant polymers, materials can be prepared that promote the localized generation of NO at their surfaces. However, the feasibility of utilizing copper-based MOFs for such applications depends on effective incorporation within a supporting polymeric matrix and the retention of useful activity thereafter. As such, it is necessary to assess different polymer/MOF composites for their ability to promote NO generation from RSNOs prior to use in medical applications. This presentation investigates the incorporation of two distinct copper-based MOFs into a selection of medically-relevant polymeric materials including cotton, poly(vinyl chloride) and chitosan.4,5,6 These polymer/MOF materials were subsequently tested for their ability to promote NO generation from RSNOs in an effort to assess the impact of incorporation within a polymer matrix, and were found to enhance NO generation 3 to 65-fold depending on the polymer system under investigation. This suggests that the ability of copper-based MOFs to enhance NO generation is impacted by the polymer. Additionally, structural analysis by pXRD and assessment of copper leaching by ICP-AES indicated these copper-based MOFs retain crystallinity and exhibit no significant degradation following exposure to RSNOs.  Overall, this work demonstrates the potential for blood-contacting MOF-containing materials in biomedical settings and provides further understanding of these hybrid materials for future optimization.

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Division(s): Materials

Speaker: Megan Neufeld

Speaker Institution: Colorado State University

Event Date: 02-17-2017

Event Time: 4:00 PM

Event Location: Chemistry A101

Mixer Time: 3:45 PM

Mixer Location: Chemistry B101E

Host: M. Reynolds