About the Seminar: Quantitative analysis of biological systems and associated components is crucial in advancing our understanding of modern biological sciences. In this talk, I will share our effort in integrating analytical chemistry, bioengineering, and material chemistry for constructing assays for quantitative bioanalysis. Specifically, I would first describe a Chip-DIA strategy for streamlined single-cell proteomic […]

About the Seminar The context in which a metal resides within a biological environment significantly influences its activity in function. Recent years have seen a rise in tools for monitoring metal ions and have illuminated the diversity in metal speciation in biology, but many of these tools are focused on probing metals in the intracellular […]

About the Seminar Essential metal ions like zinc, copper, and iron have a broad range of signaling, stabilizing, and catalytic functions across all living systems. The gut microbiota typically acquires these metals through the host diet but must be able to adapt to dietary fluctuations. Many studies link changes in available metal nutrients to alterations […]

About the Seminar:  Several methods are now available which are able to extend the resolution of optical microscopes beyond the diffraction limit. These methods include photoactivated localization microscopy, stochastic optical reconstruction microscopy, stimulated emission depletion microscopy, and super-resolution structured illumination microscopy (SIM). In many situations, SIM is the most useful super-resolution method for imaging live […]

Join us for the November Colorado ACS Meeting What to Do When Your Published Results Are Questioned Presentation by: Dr. George Stanley Colorado State University & Louisiana State University Chair-Elect of Colorado Section of ACS Monday, Nov. 14, 2022, 4:00 pm, A101 Colorado State University 1301 Center Ave., Fort Collins, Colorado 80523   About the […]

About the Seminar: Imaging techniques are a vital part of clinical diagnostics and biomedical research. Optical molecular imaging makes use of relatively harmless, low-energy light, and technically straightforward instrumentation. Bioluminescence imaging systems, particularly use of firefly luciferin, are attractive because they have inherently high signal contrast due to the lack of background emission. However, current […]

About the Seminar: Hops are one of the four primary raw ingredients used to make beer and they are employed by brewers to impart specific flavor and aroma profiles, particularly in craft beer styles.   These unique sensory attributes are a result of chemical compounds in hops such as alpha acids and terpenes which can vary […]

Research Seminar Barcoding technology for object tracking continues to evolve in form, complexity and security. Recently, DNA has been used as a barcode allowing the user to encode information within the nucleic sequence, increasing the material’s storage density. However, the susceptibility of DNA to environmental damage (e.g., nuclease and ultraviolet (uv) light exposure) limits the […]

Research Seminar The visualization of molecular-level processes within living organisms should be considered a cornerstone of next-generation medicine. To that end, ultrasound can noninvasively image deep tissue with high spatiotemporal resolution but is lacking in molecular-level biosensors analogously available to other imaging modalities1. Gas vesicle (GV) protein nanostructures have recently been proposed as ultrasound contrast […]

About the Seminar: We report a 100-million atom-scale model of an entire cell organelle, a photosynthetic chromatophore vesicle from a purple bacterium, that reveals the cascade of energy conversion steps culminating in the generation of ATP from sunlight. Molecular dynamics simulations of this vesicle elucidate how the integral membrane complexes influence local curvature to tune […]

About the Seminar Critical for numerous cellular functions is the dynamic interplay between cell surface receptors, small GTPases, and the enzymes that synthesize phosphatidylinositol phosphate (PIP) lipids. Using human neutrophils as a model system for cell polarity and migration, we find that small GTPases and PIP lipid modifying enzymes trigger a molecular signal that propagates […]

The functions of many RNA molecules – including mRNAs, long non-coding RNAs, and the genomes of RNA viruses – require that an RNA fold back on itself to create intricately and complexly folded structures. Until recently, however, we had little idea of the broad interrelationships between RNA structure and function because there simply did not […]

4th Year Proposal Seminar   Teams Link: Microsoft Teams Link

About the Seminar Influenza A viruses (IAV) are major human respiratory pathogens that cause annual epidemics and occasional pandemics globally. IAV has evolved its viral proteins to interact with cellular proteins to aid in the regulation of viral replication and ultimately cause disease pathogenesis. More specifically, the ribonucleoprotein complexes (RNPs) interact with many host cell […]

About the Seminar The viral matrix protein (VP40) is crucial to multiple steps of the Ebola Virus (EBOV) lifecycle, including the regulation of transcription and viral egress. In the cytosol, VP40 monomers spontaneously dimerize and migrate to the inner-cell membrane where a reorientation causes partial penetration of the membrane and hexamer formation. Further oligomerization of […]

Research Seminar Abstract The insulin receptor (IR) and insulin-like growth factor receptor (IGF1R) system is implicated in the pathogenesis of breast cancer. As members of the tyrosine kinase receptor family, these receptors are able to dimerize in different combinations forming IR-IR and IGF1R-IGF1R homodimers and IR-IGF1R heterodimers. Overexpression of one and/or both receptors on the […]

About the Seminar: Cells are material objects with specific mechanical properties, which are important for proper function, but unlike passive substances, the material properties of cells are strongly affected by life processes. In this talk I will discuss two aspects of cells as active materials, which my lab has been interested in. Firstly, cells are […]

We and others have demonstrated the use of triaminotriazine (melamine) as a synthetic base-triple motif in a family of molecules we call bifacial peptide nucleic acid (bPNA). Bifacial PNA engages two oligo T/U strands simultaneously to form a unique triple stranded structure. bPNAs can serve as allosteric triggers of aptamer protein-binding, ribozyme catalysis, aptamer small-molecule […]

The Nature Research portfolio includes the flagship Nature title, the physical and life sciences research journals, such as Nature Chemistry, and the open-access titles including the newly launched Communications Chemistry. During the first part of the talk Andrew will discuss the different aims and scopes of the various Nature titles as well as the relationship […]

The lecture will provide a brief introduction to biocatalytic methods in synthesis. Specifically, the use of various aromatic dioxygenase enzymes will be highlighted and their applications in total synthesis will be presented. These include several total syntheses of morphine alkaloids, total synthesis of Amaryllidaceae alkaloids and their medicinally useful derivatives, and approaches to other, highly […]